Chondromyxoid Fibroma: Bone Chondromyxoid Neoplasia is a rare lesion in bone tissue, which manifests itself in the metaphysis of long bones in an eccentric manner. Characterized by a lobulated appearance, it presents an internal halo of bone sclerosis that separates it from the surrounding normal tissue, often accompanied by cortical erosion, denoting a certain local aggressiveness. The presence of calcifications within it is a common feature of all cartilaginous lesions.

From a histological point of view, Chondromyxoid Fibroma exhibits notable cellular pleomorphism, with the presence of areas of chondroid, fibrous tissue and a significant amount of myxoid material, often accompanied by multinucleated giant cells.

This type of injury may also be associated with an aneurysmal bone cyst, being most commonly found in the proximal metaphysis of the tibia, mainly affecting adolescents and young adults.

The standard treatment for Chondromyxoid Fibroma is surgery. Generally, the approach involves partial parietal resection of the lesion, accompanied by local adjuvant measures, such as the use of phenol, electrothermia or liquid nitrogen, in addition to bone grafting when necessary. In more advanced cases, segmental resection may be indicated. Curettage can also be used, especially in joint regions, but it must be carried out carefully to avoid recurrences.

In short, Chondromyxoid Fibroma is an uncommon bone lesion, but it requires an appropriate surgical approach to avoid complications and guarantee a satisfactory recovery for the patient.